منابع مشابه
Vertex Bisection is Hard, too
We settle an open problem mentioned in Diaz, Petit, and Serna: A survey of graph layout problems (ACM Computing Surveys 34:313–356, 2002). Of eight objectives considered in that survey, only the complexity status of minimum vertex bisection is listed as unknown. We show that both minimum and maximum vertex bisection are NP-hard, but polynomially solvable on special graph classes such as hypercu...
متن کاملTaking a Break From Huntingtin
1Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. Correspondence: Beverly L Davidson, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. E-mail: [email protected] Three groups have forged an important collaboration to test the utility of antisense oligonucleotides (ASO...
متن کاملToo hard to face.
While the Holocaust is often placed at the genesis of bioethics, this relatively young field has not yet seriously explored the conduct of German scientists and physicians involved in the human subjects experiments of the Holocaust. We comfort ourselves with the beliefs that the individuals involved in the events of the Holocaust were mad or evil and unlike other scientists and physicians. Yet ...
متن کاملSENS is hard , yes , but not too hard to try : a reply to Warner
Elsewhere in this issue, Huber Warner writes a critique of my “Strategies for Engineered Negligible Senescence” (SENS) proposal for the dramatic postponement of age-related functional decline. His commentary advances the debate on SENS to a proper level of measured discourse, something that has been regrettably lacking hitherto, and for this I applaud him. However, his conclusion that SENS is c...
متن کاملHuntington’s Disease: a Hard Nut to Break
Huntington’s disease (HD) is an autosomal dominantly inherited progressive neurodegenerative disorder, characterized by progressively worsening chorea, psychiatric disturbances, cognitive impairment and weight loss. The degenerative process primarily involves medium spiny striatal neurons (MSN) and to a lesser extent cortical neurons. Importantly, γ-amino butyric acid (GABA)ergic projection neu...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.364.6435.98